The subcabinet was first established by Governor Walz in April 2022 via Executive Order 22-07.
Later that year, the Legislature codified the provisions of Executive Order 22-07 in Laws of Minnesota 2022, chap. 98, art. 6, sec. 1. Gov. Walz then issued Executive Order 22-14, rescinding the executive order that had first established the subcabinet, in light of the fact that the subcabinet was now codified in law.
The Governor's Advisory Council on Opioids, Substance Use, and Addiction was also established in Executive Order 22-07 and it's purpose was to advise the subcabinet in its duties. It was also codified in law by the Legislature in 2022.